Research Focus

Bioinformatics and Data Mining

Using omics, data mining, and multimodal integration to connect autoimmune disease, TCM patterning, and objective measurement.

My perspective

My interest in bioinformatics goes beyond using it as a tool. I see it as a bridge: one side faces complex clinical phenomena, and the other faces molecular signals and computational models. In heterogeneous conditions such as Sjögren’s syndrome, dry eye, and TCM patterning, progress is difficult without data mining and multi-omics thinking.

What I care about most in this area

Heterogeneity is central

Autoimmune disease and TCM patterning are both highly heterogeneous.

Multimodal integration matters

I care about how HRV, tongue diagnosis, symptom scales, proteomics, transcriptomics, and exosomes can be studied together.

From correlation to explanation

Data mining should help generate testable mechanistic hypotheses.

Building the future AIDDES platform

This is foundational for AI and smart medicine extensions of my work.

Representative papers

Genotyping of human neutrophil antigens from whole genome sequencing data (2013)Reflects my early exposure to genomic analysis.

Quantitative assessment of mitochondrial DNA copies from whole genome sequencing (2012)Shows my earlier training in molecular data analysis.

Unveiling the Age-Related Dynamics in Sjögren's Syndrome (2024)A more recent example linking data analysis back to Sjögren’s syndrome and HRV.

Representative projects

I list each directly relevant project separately here, including both NSTC and hospital-based projects. If this website does not currently contain a standalone project for this theme, I leave it blank rather than forcing a match.

NSTC 113-2320-B-A49-029Exosome-miRNA and transcriptome profilingNSTC project

V114C-078Proteomic analysis of plasma exosomesHospital project

V115C-111TBDESJS on an integrated lipid metabolism and immune-response platformHospital project

V108B-031DNA exome, constitution, tongue, and pulse on one platformHospital project

V109B-034Integrated functional proteomics and oral microbiomeHospital project

Teaching links

Workshop on smart medicine in objective TCM standardizationAn important intersection of teaching and research for me.