Research Focus

Clinical Trial Design and Translational Application

Designing clinically meaningful trials and outcome frameworks that can move from patient problems to translational research.

My perspective

I believe a good clinical trial does far more than compare two interventions. It has to start by asking whether the question matters to patients, whether the endpoints are truly meaningful, and whether the results can point toward deeper mechanistic work. That is the research design attitude I care about most.

What I care about most in this area

The question should come from practice

I prefer to start from real patient problems rather than looking for a method first.

Endpoints must be convincing

I care a great deal about how symptom scales, objective measures, and biomarkers are arranged.

A trial is not the endpoint

Clinical trials should open the door to mechanism, biomarkers, and translational pathways.

Methodology is also part of training

I teach trial thinking because asking the right question is itself a core academic skill.

Representative papers

The Impact of Alpha-s1 Casein Hydrolysate on Chronic Insomnia (2024)A good example of combining symptoms, objective measures, and trial design.

Evaluation of TBDESJS in Patients with SJS and DES (2024)Shows how herbal intervention can be studied in a structured clinical setting.

Laser acupuncture for carpal tunnel syndrome (2019)An earlier intervention study that reflects my methodological development.

Representative projects

I list each directly relevant project separately here, including both NSTC and hospital-based projects. If this website does not currently contain a standalone project for this theme, I leave it blank rather than forcing a match.

NSTC 114-2628-B-A49-006-MY3Electroacupuncture at GB20 for dry eye: efficacy and mechanism analysisClinical trial and mechanism integration

NSTC 113-2320-B-A49-029Exosome-miRNA and transcriptome profiling for sicca symptom alleviationNSTC project

V113C-087VGH-DESJS-1 clinical application and exosome mechanism studyHospital project

V112C-190VGH-DESJS-1 clinical applicationHospital project

Teaching links

Teaching: How should university students conduct TCM research?This reflects how I connect research design with education.

Column: Reviewing is both a responsibility and a journey of growthShows my broader view of research quality and methodology.